Multiplying and dividing with negative numbers comes down to a single rule about signs. Once you know what sign the answer should have, you work out the size exactly as you always have.
Same signs give a positive answer. Different signs give a negative answer. That holds for multiplication and division alike:
So
Read off the sign of either operand along an edge; the cell where they meet is the sign of the answer. The diagonal of matching signs is positive; the off-diagonal of mixed signs is negative.